Gender MaleFemale
Race BlackNon-Black
Smoker YesNo

CVD risk is reversed after 5-10 years of no smoking

Diabetes YesNo

Systolic Blood Pressure


120 mmHg is used for baseline risk

On treatment for BP YesNo

Only applies if SBP is greater than 120 mmHg

Total Cholesterol


3 mmol/L is used for baseline risk.
Click to change to mg/dL.

116 mg/dL is used for baseline risk.
Click to change to mmol/L.

HDL Cholesterol


1.3 mmol/L is used for baseline risk.

50 mg/dL is used for baseline risk.

Family History of CVD YesNo

Angina or heart attack in a 1st degree relative < 60 yrs

Chronic Kidney Disease YesNo
Atrial Fibrillation YesNo
Rheumatoid Arthritis YesNo





BMI of 25 kg/m2 for baseline risk

Relative Benefit:  0%

Benefit often has nothing to do with the effect on the surrogate marker. At present, you can only select one intervention at a time.

  • Physical Activity
  • Mediterranean Diet vs Low fat
  • Vitamin/Omega-3 supplements
  • BP meds (not atenolol/doxazosin)
  • Low-mod intensity statins
  • High intensity statins
  • Fibrates
  • Niacin
  • Ezetimibe
  • Metformin
  • Sulfonylureas
  • Insulins
  • Glitazones
  • GLPs
  • DPP-4s
  • Meglitinides
  • ASA
Benefit Estimate Details

Family History of Early CHD

If mother (< 65 yrs) increase risk 60%

If father (< 55 yrs) increase risk 75%

Risk Time Period


Adjust Overall Risk


The amount of risk conferred from a family member to a patient depends on: (1) how close a relative, (2) age of a relative, (3) number of affected family members.

No event
Total with an event
Number who benefit from treatment
NNT % Number needed to treat
Baseline events using baseline factors alone
Additional events “caused” by risk factors

As with all risk calculators, calculated risk numbers are +/- 5% at best. More information.

See the QRISK®2 disclaimer for more information.